(1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde

Base Information

• Chemical Name: (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde
• CAS No.: 145414-40-0
• Molecular Formula: C₁₉H₁₈O₂
• Molecular Weight: 278.351
• Mol file: 145414-40-0.mol

Synonyms:(1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde

Chemical Property of (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde

There total 3 articles about (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(1R,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde (145351-73-1) → (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde (145414-40-0)

Guidance literature:

With triethylamine; In toluene; at 90 ℃; for 4h;

Reference yield:

(1S,4R,5S)-5-(2,2-Diphenyl-vinyl)-2-oxa-bicyclo[2.1.1]hexan-3-one (92776-59-5,145414-36-4) → (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde (145414-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / p-MeC₆H₄SO₃H / 12 h / Ambient temperature

2: 74 percent / diisobutylaluminiumhydride (DIBAL-H) / toluene / 2 h / -100 °C

3: 60 percent / triethylamine / toluene / 4 h / 90 °C

With diisobutylaluminium hydride; triethylamine; toluene-4-sulfonic acid; In toluene;

Reference yield:

(1R,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarboxylic acid methyl ester (145414-37-5) → (1S,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde (145414-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / diisobutylaluminiumhydride (DIBAL-H) / toluene / 2 h / -100 °C

2: 60 percent / triethylamine / toluene / 4 h / 90 °C

With diisobutylaluminium hydride; triethylamine; In toluene;

upstream raw materials:

(1R,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarbaldehyde

(1S,4R,5S)-5-(2,2-Diphenyl-vinyl)-2-oxa-bicyclo[2.1.1]hexan-3-one

(1R,2R,3S)-2-(2,2-Diphenyl-vinyl)-3-hydroxy-cyclobutanecarboxylic acid methyl ester

Downstream raw materials:

C₅₁H₅₆O₂Si₂