((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate

Base Information

• Chemical Name: ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate
• CAS No.: 905581-37-5
• Molecular Formula: C₃₂H₃₀ClN₅O₆S
• Molecular Weight: 648.139

Synonyms:((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate

Chemical Property of ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate

Chemical Property:

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Technology Process of ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate

There total 1 articles about ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2',3'-isopropylidene-5'-O-sulfamoyl-6-chloropurineriboside (905580-15-6) + trityl chloride (76-83-5) → ((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate (905581-37-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 56.0%

((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate (905581-37-5) + tri-n-butyl(vinyl)tin (7486-35-3) → [(3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-vinyl-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl tritylsulfamate (905581-43-3)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; for 4.5h; Heating / reflux;

Reference yield: 55.0%

((3aR,4R,6R,6aR)-6-(6-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d][1,3]dioxol-4-yl)methyl tritylsulfamate (905581-37-5) + N-methyl-1(S)-aminoindan (66512-63-8) → ((3aR,4R,6R,6aR)-6-{6-[(1S)-2,3-dihydro-1H-inden-1-yl(methyl)amino]-9H-purin-9-yl}-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 150 ℃; for 0.166667h; Microwave irradiation;

upstream raw materials:

2',3'-isopropylidene-5'-O-sulfamoyl-6-chloropurineriboside

trityl chloride

Downstream raw materials:

[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-vinyl-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl tritylsulfamate

[(3aR,4R,6R,6aR)-6-{6-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-methyl]-9H-purine-9-yl}-2,2-dimethyltetrahyrofuro[3,4-d][1,3]dioxol-4-yl]-methyl tritylsulfamate

[(3aR,4R,6R,6aR)-6-{6-[(2,3-dihydro-1H-inden-2-yl)methyl]-9H-purine-9-yl}-2,2-dimethyltetrahyrofuro[3,4-d][1,3]dioxol-4-yl]-methyl tritylsulfamate

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