4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol

Base Information

• Chemical Name: 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol
• CAS No.: 221564-99-4
• Molecular Formula: C₃₄H₅₆N₆O₈Si₂
• Molecular Weight: 733.025
• Mol file: 221564-99-4.mol

Synonyms:4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol

Chemical Property of 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol

There total 1 articles about 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydroxybutylamine (83430-32-4) + 3′,5′-O-bis(tert-butyldimethylsilyl)-O6-(p-nitrophenylethyl)-2′-deoxy-2-fluoroguanosine (190506-33-3) → 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol (221564-99-4)

Guidance literature:

With calcium chloride; In methanol; at 58 ℃; for 16h;

DOI:10.1021/jm980605u

Reference yield:

4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol (221564-99-4) → Acetic acid 1-acetoxymethyl-3-{9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphoryloxy]-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 16 h / Ambient temperature

2: HF, pyridine / 4 h / Ambient temperature

3: pyridine / 1 h / Ambient temperature

4: NEt₃ / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; hydrogen fluoride; triethylamine; In dichloromethane;

DOI:10.1021/jm980605u

Reference yield:

4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol (221564-99-4) → Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester (221565-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / Ambient temperature

2: HF, pyridine / 4 h / Ambient temperature

With pyridine; hydrogen fluoride;

DOI:10.1021/jm980605u

upstream raw materials:

3,4-dihydroxybutylamine

3′,5′-O-bis(tert-butyldimethylsilyl)-O⁶-(p-nitrophenylethyl)-2′-deoxy-2-fluoroguanosine

Downstream raw materials:

acetic acid 1-acetoxymethyl-3-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

Acetic acid 1-acetoxymethyl-3-{9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester