(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

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Chemical Name:(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol
CAS No.:139109-00-5
Molecular Formula:C₄₆H₆₈O₂Si
Molecular Weight:681.13
Hs Code.:

(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

Synonyms:(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

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Chemical Property of (2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

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Technology Process of (2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

There total 13 articles about (2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 139108-91-1
(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dienoic acid methyl ester

: 139109-00-5
(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4020(97)10260-5

Reference yield:

: 201799-09-9
(Z)-8-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-oct-6-enoic acid methyl ester

: 139109-00-5
(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: 7 mg / DBU / toluene / 4 h / Heating

3: 85 percent / DIBAH / toluene / 0.5 h / -78 °C

With diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; toluene;
DOI:10.1016/S0040-4020(97)10260-5

Reference yield:

: 139108-85-3
isocopalenyl iodide

: 139109-00-5
(2E,6Z)-8-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-2-[2-((1S,4aS,4bR,8aR,10aR)-2,4b,8,8,10a-pentamethyl-1,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydro-phenanthren-1-yl)-ethyl]-octa-2,6-dien-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / n-Bu₃SnH / diethyl ether / 11 h / Irradiation

2: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

3: 7 mg / DBU / toluene / 4 h / Heating

4: 85 percent / DIBAH / toluene / 0.5 h / -78 °C

With tri-n-butyl-tin hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1016/S0040-4020(97)10260-5