(S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Name:(S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373278-81-9
Molecular Formula:C₃₃H₃₁F₂N₃O₅
Molecular Weight:587.623
Hs Code.:

Synonyms:(S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of (S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of (S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 11 articles about (S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373278-14-8
tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 179249-15-1,179249-16-2
(R)-1-(4-fluorophenyl)prop-2-yn-1-ol

: 1373278-81-9
(S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With sodium hypochlorite; at 20 ℃; sealed tube;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1373278-81-9
(S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.2: 16 h / 60 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

8.1: sodium hypochlorite / 20 °C / sealed tube

With pyridine; sodium hypochlorite; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373278-81-9
(S)-tert-butyl 5-(3-(4-fluorophenyl)-7-(5-((4-fluorophenyl)(hydroxy)methyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.2: 16 h / 60 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

8.1: sodium hypochlorite / 20 °C / sealed tube

With pyridine; sodium hypochlorite; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;