tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Base Information

Chemical Name:tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373278-14-8
Molecular Formula:C₂₄H₂₆FN₃O₄
Molecular Weight:439.487
Hs Code.:

Synonyms:tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 8 articles about tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373278-13-7
tert-butyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373278-14-8
tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With pyridine; hydroxylamine hydrochloride; at 20 ℃; for 2h;

Reference yield:

: 917889-25-9
3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester

: 1373278-14-8
tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.2: 16 h / 60 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

With pyridine; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1373278-10-4
methyl 2-(5-tert-butoxy-5-oxopentyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

: 1373278-14-8
tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

With pyridine; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;