1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride

Base Information

• Chemical Name: 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride
• CAS No.: 906481-48-9
• Molecular Formula: C₁₁H₅Cl₂F₃N₂O
• Molecular Weight: 309.075
• Mol file: 906481-48-9.mol

Synonyms:1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride

Chemical Property of 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride

There total 3 articles about 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazolecarboxylic acid (1152972-16-1) → 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride (906481-48-9)

Guidance literature:

With thionyl chloride; Reflux;

Reference yield:

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one (321-07-3) → 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride (906481-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate

2: potassium permanganate

3: thionyl chloride

With potassium permanganate; thionyl chloride; trichlorophosphate; 1: Vilsmeier-Haack reaction;

DOI:10.1002/jhet.591

Reference yield:

5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde (318288-78-7) → 1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazoloyl chloride (906481-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate

2: thionyl chloride

With potassium permanganate; thionyl chloride;

DOI:10.1002/jhet.591

upstream raw materials:

5‐chloro‐1‐phenyl‐3‐(trifluoromethyl)‐1H‐pyrazole‐4‐carbaldehyde

1-phenyl-3-trifluoromethyl-5-chloro-4-pyrazolecarboxylic acid

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one

Downstream raw materials:

dipropyl((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate

diisopropyl((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate

dibutyl((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamido)(phenyl)methyl)phosphonate

bis(2-methoxyethyl)((5-chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carbo-xamido)(phenyl)methyl)phosphonate