321-07-3Relevant articles and documents
Covalent inhibitors of LgtC: A blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases
Xu, Yong,Smith, Ruth,Vivoli, Mirella,Ema, Masaki,Goos, Niina,Gehrke, Sebastian,Harmer, Nicholas J.,Wagner, Gerd K.
, p. 3182 - 3194 (2017)
Non-substrate-like inhibitors of glycosyltransferases are sought after as chemical tools and potential lead compounds for medicinal chemistry, chemical biology and drug discovery. Here, we describe the discovery of a novel small molecular inhibitor chemot
Trifluoromethyl pyrazolo seven-membered ring compound and crystal structure and preparation method thereof
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Paragraph 0012; 0040-0041, (2021/10/27)
The invention provides a trifluoromethyl pyrazolo seven-membered ring compound and a crystal structure and a preparation method thereof, and belongs to the technical field of organic and pharmaceutical synthesis. The invention provides a novel trifluoromethyl pyrazolo seven-membered ring compound, a crystal thereof and a preparation method thereof. The compound and the crystal have good stability and are suitable for being used as raw materials for medicine preparation; and meanwhile, data support is provided for exploring the relationship between the microstructure and the medicine effect of the compound, and a certain basis is provided for synthesis of small molecular compounds.
Electrochemical synthesis of versatile ammonium oxides under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions
Yuan, Yong,Li, Liang-Sen,Zhang, Lin,Wang, Feng,Jiang, Lin,Zuo, Lin,Wang, Qi,Hu, Jian-Guo,Lei, Aiwen
supporting information, p. 2768 - 2771 (2021/03/23)
An electrochemical oxidative cross-coupling reaction between 2.5-substituted-pyrazolin-5-ones and ammonium thiocyanate has been developed, which resulted in a series of unprecedented cross-coupling products under metal catalyst-, exogenous-oxidant-, and exogenous-electrolyte-free conditions. It is worth noting that since the resulting cross-coupling products are nearly insoluble in MeCN, the pure product could be afforded without silica gel column purification. In addition, the prepared ammonium oxides are versatile building blocks for synthesizing functionalized pyrazole derivatives.
Synthesis and cytotoxicity evaluation of novel tricyclic dihydropyrazolo [4,3-f][1,2,3]triazolo diazepines
Bingi, Chiranjeevi,Kale, Ashok,Poornachandra, Yedla,Kumar, Chityal Ganesh,Atmakur, Krishnaiah
, p. 1020 - 1025 (2018/10/31)
Background: A number of novel fluorinated 4,5-dihydropyrazolo [4,3-f][1,2,3] triazolo diazepines (9-11) have been accomplished starting from 1-phenyl-3-trifluoromethyl pyrazole-5-one (3) in a multistep synthesis. Thus obtained compound 9 was converted int
