2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Base Information

Chemical Name:2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol
CAS No.:1450622-12-4
Molecular Formula:C₂₈H₂₉F₆N₃O₄SSi
Molecular Weight:645.698
Hs Code.:

Synonyms:2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Chemical Property of 2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

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Technology Process of 2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

There total 8 articles about 2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450622-06-6
2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-chloro-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 1450622-12-4
2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: With potassium carbonate; caesium carbonate; In N,N-dimethyl acetamide; at 110 ℃; for 2h; Sealed tube; Inert atmosphere;

Reference yield:

: 1361221-42-2
5-((4-bromophenyl)sulfanyl)-2-chloropyridine

: 1450622-12-4
2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: ammonium hydroxide / ethanol / 18 h / 120 °C / Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere; Sealed tube

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / Inert atmosphere

5: caesium carbonate; potassium carbonate / N,N-dimethyl acetamide / 2 h / 110 °C / Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; potassium acetate; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 1361221-43-3
5-((4-bromophenyl)sulfonyl)-2-chloropyridine

: 1450622-12-4
2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / ethanol / 18 h / 120 °C / Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere; Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / Inert atmosphere

4: caesium carbonate; potassium carbonate / N,N-dimethyl acetamide / 2 h / 110 °C / Sealed tube; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; potassium acetate; potassium carbonate; caesium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; N,N-dimethyl acetamide; water;