3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

Base Information

Chemical Name:3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol
CAS No.:1450622-11-3
Molecular Formula:C₂₂H₁₅F₆N₃O₄S
Molecular Weight:531.435
Hs Code.:

Synonyms:3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

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Chemical Property of 3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

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Technology Process of 3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

There total 9 articles about 3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1450622-12-4
2-(6-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(3-((tert-butyl(dimethyl)silyl)oxy)-1-propyn-1-yl)-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1450622-11-3
3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm5018175

Reference yield:

: 1361221-42-2
5-((4-bromophenyl)sulfanyl)-2-chloropyridine

: 1450622-11-3
3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: ammonium hydroxide / ethanol / 18 h / 120 °C / Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere; Sealed tube

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / Inert atmosphere

5: caesium carbonate; potassium carbonate / N,N-dimethyl acetamide / 2 h / 110 °C / Sealed tube; Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; tetrabutyl ammonium fluoride; potassium acetate; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 1361221-43-3
5-((4-bromophenyl)sulfonyl)-2-chloropyridine

: 1450622-11-3
3-(2-(4-((6-amino-3-pyridinyl)sulfonyl)phenyl)-5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-3-pyridinyl)-2-propyn-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / ethanol / 18 h / 120 °C / Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere; Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,2-dimethoxyethane / Inert atmosphere

4: caesium carbonate; potassium carbonate / N,N-dimethyl acetamide / 2 h / 110 °C / Sealed tube; Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; tetrabutyl ammonium fluoride; potassium acetate; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; N,N-dimethyl acetamide; water;