2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid

Base Information

Chemical Name:2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid
CAS No.:1309656-46-9
Molecular Formula:C₁₉H₂₅N₂O₅P
Molecular Weight:392.392
Hs Code.:

Synonyms:2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid

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Chemical Property of 2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid

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Technology Process of 2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid

There total 2 articles about 2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₁N₂O₇P

: 1309656-46-9
2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid

Guidance literature:: With hydrogen bromide; In acetic acid; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2011.04.037

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 234452-57-4
(1-{[(benzyloxy)carbonyl]amino}-3-phenylpropyl)phosphinic acid

: 1309656-46-9
2-(S)-N-{[(1'-(R,S)-amino-3'-phenylpropyl)(hydroxy)phosphinyl]methyl}amino-3-(p-hydroxyphenyl)propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; acetic acid / 1 h / Reflux

2: hydrogen bromide / acetic acid / 2 h / 20 °C

With hydrogenchloride; hydrogen bromide; In water; acetic acid; 1: Mannich reaction;
DOI:10.1016/j.tetlet.2011.04.037