[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester

Base Information

• Chemical Name: [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester
• CAS No.: 120609-32-7
• Molecular Formula: C₁₇H₂₆NO₆P
• Molecular Weight: 371.37
• Mol file: 120609-32-7.mol

Synonyms:[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester

Chemical Property of [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester

There total 1 articles about [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl bromoacetate (105-36-2) + <1(R)-<(benzyloxycarbonyl)amino>-3-methylbutyl>phosphinic acid (120707-56-4) → [((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester (120609-32-7)

Guidance literature:

With chloro-trimethyl-silane; triethylamine; Yield given. Multistep reaction; 1.) THF, r.t., 2.) 2 h;

DOI:10.1021/jm00127a041

Reference yield: 78.0%

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester (120609-32-7) → 2--3-methylbutyl>phosphinyl>acetic acid (120609-66-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 16h; Ambient temperature;

DOI:10.1021/jm00127a041

Reference yield:

[((R)-1-Benzyloxycarbonylamino-3-methyl-butyl)-hydroxy-phosphinoyl]-acetic acid ethyl ester (120609-32-7) → 2--3-methylbutyl>phosphinyl>acetyl-L-isoleucyl-L-histidine amide

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NaOH / ethanol; H₂O / 16 h / Ambient temperature

2: 88 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00127a041

upstream raw materials:

ethyl bromoacetate

<1(R)-<(benzyloxycarbonyl)amino>-3-methylbutyl>phosphinic acid

Downstream raw materials:

2--3-methylbutyl>phosphinyl>acetic acid