methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

Base Information

Chemical Name:methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate
CAS No.:1239963-40-6
Molecular Formula:C₃₁H₂₈Cl₂F₃N₃O₄S
Molecular Weight:666.548
Hs Code.:

Synonyms:methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

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Chemical Property of methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

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Technology Process of methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

There total 8 articles about methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239956-73-0
4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 1239963-40-6
methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 455-40-3
3,5-difluorobenzoic acid

: 1239963-40-6
methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid; magnesium sulfate / toluene / 20 °C

2: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 3 h / -78 °C

3: sodium tetrahydroborate / methanol / 0.33 h / 0 °C

4: triethylamine / dichloromethane / 0.5 h / 0 °C

5: potassium carbonate / acetone / 1.25 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

7: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sulfuric acid; magnesium sulfate; potassium carbonate; triethylamine; diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; hexanes; dichloromethane; acetone; toluene;

Reference yield:

: 1239964-17-0
tert-butyl 3,5-difluoro-4-(hydroxymethyl)benzoate

: 1239963-40-6
methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: potassium carbonate / acetone / 1.25 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

4: triethylamine; HATU / dichloromethane / 16 h / 20 °C

With potassium carbonate; triethylamine; HATU; trifluoroacetic acid; In dichloromethane; acetone;