3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

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Chemical Name:3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid
CAS No.:1239956-79-6
Molecular Formula:C₃₀H₂₆Cl₂F₃N₃O₄S
Molecular Weight:652.521
Hs Code.:

Synonyms:3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

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Chemical Property of 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

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Technology Process of 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

There total 9 articles about 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239963-40-6
methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate

: 1239956-79-6
3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

Guidance literature:: methyl 3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoate; With water; sodium hydroxide; In methanol; at 20 ℃; for 1.66667h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 455-40-3
3,5-difluorobenzoic acid

: 1239956-79-6
3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; magnesium sulfate / toluene / 20 °C

2: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 3 h / -78 °C

3: sodium tetrahydroborate / methanol / 0.33 h / 0 °C

4: triethylamine / dichloromethane / 0.5 h / 0 °C

5: potassium carbonate / acetone / 1.25 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

7: triethylamine; HATU / dichloromethane / 16 h / 20 °C

8: water; sodium hydroxide / methanol / 1.67 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sulfuric acid; water; magnesium sulfate; potassium carbonate; triethylamine; diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexanes; dichloromethane; acetone; toluene;

Reference yield:

: 1239964-17-0
tert-butyl 3,5-difluoro-4-(hydroxymethyl)benzoate

: 1239956-79-6
3-(4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzamido)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: potassium carbonate / acetone / 1.25 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

4: triethylamine; HATU / dichloromethane / 16 h / 20 °C

5: water; sodium hydroxide / methanol / 1.67 h / 20 °C

With water; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; acetone;