(3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate
• CAS No.: 1258299-43-2
• Molecular Formula: C₃₇H₄₉FN₄O₅
• Molecular Weight: 648.818

Synonyms:(3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

Chemical Property of (3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

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Technology Process of (3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate

There total 1 articles about (3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate (1258299-40-9) + 2-(3-Fluorophenyl)ethylamine (404-70-6) → (3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate (1258299-43-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2010.08.096

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + (3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(3-fluorophenethylamino)ethoxy)pyrrolidine-1-carboxylate (1258299-43-2) → (3R,4R)-tert-Butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(tertbutoxycarbonyl-(3-fluorophenethyl)amino)ethoxy)pyrrolidine-1-carboxylate (1258299-45-4)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2010.08.096

upstream raw materials:

(3S,4S)-tert-butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate

2-(3-Fluorophenyl)ethylamine

Downstream raw materials:

(3R,4R)-tert-Butyl 3-((6-(benzyl(tert-butoxycarbonyl)amino)pyridin-2-yl)methyl)-4-(2-(tertbutoxycarbonyl-(3-fluorophenethyl)amino)ethoxy)pyrrolidine-1-carboxylate

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