3-Fluorophenethylamine

Base Information

• Chemical Name: 3-Fluorophenethylamine
• CAS No.: 404-70-6
• Molecular Formula: C8H10FN
• Molecular Weight: 139.173
• Hs Code.: 29214990
• Mol file: 404-70-6.mol

Synonyms:Phenethylamine,m-fluoro- (8CI);2-(3-Fluorophenyl)ethanamine;2-(3-Fluorophenyl)ethylamine;3-Fluorobenzeneethanamine;m-Fluorophenylethylamine;

Chemical Property of 3-Fluorophenethylamine

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow liquid
• Vapor Pressure: 0.425mmHg at 25°C
• Refractive Index: n20/D 1.509(lit.)
• Boiling Point: 195.2 °C at 760 mmHg
• PKA: 9.65±0.10(Predicted)
• Flash Point: 82.8 °C
• PSA: 26.02000
• Density: 1.069 g/cm³
• LogP: 2.02720
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3-Fluorophenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluorophenethylamine may be used in the synthesis of:N-(3-florophenyl)ethylcaffeamide and its anti-inflammatory activity was evaluatedN-{2-[(3-fluorophenyl)ethyl]}-2-methylpropanamideN-(3′-fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol

Technology Process of 3-Fluorophenethylamine

There total 10 articles about 3-Fluorophenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-fluorophenylacetonitrile (501-00-8) → 2-(3-Fluorophenyl)ethylamine (404-70-6)

Guidance literature:

With potassium borohydride; copper dichloride; In water; isopropyl alcohol; at 60 ℃; for 8h;

DOI:10.14233/ajchem.2015.18836

Reference yield:

3-fluorostyrene (350-51-6) → 2-(3-Fluorophenyl)ethylamine (404-70-6)

Guidance literature:

With D-Glucose; ammonia; oxygen; In aq. phosphate buffer; at 30 ℃; for 10h; regioselective reaction; Green chemistry;

DOI:10.1021/acscatal.7b01464

Reference yield:

1-(Bromomethyl)-3-fluorobenzene (456-41-7) → 2-(3-Fluorophenyl)ethylamine (404-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 30 °C

2: ammonium hydroxide / nickel / tetrahydrofuran / 30 °C / pH 10

With ammonium hydroxide; nickel; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

3-fluorophenylalanine

3-(3-fluorophenyl)propanamide

3-fluorophenylacetonitrile

3-(3-fluorophenyl)propionic acid

Downstream raw materials:

3-{2-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-(3,5-dihydroxy-phenyl)-ethylamino]-2-methyl-propyl}-N-[2-(3-fluoro-phenyl)-ethyl]-benzamide

(2RS,3R)-3-amino-4-cyclohexyl-N-(3-fluorophenethyl)-2-hydroxybutanamide hydrochloride

Refernces

• 1、 Wu, Shuke,Liu, Ji,Li, Zhi. "Biocatalytic Formal Anti-Markovnikov Hydroamination and Hydration of Aryl Alkenes". . p. 5225 - 5233. Retrieved 2017/08/17.
• 2、 -. "DOLASTATIN-10 DERIVATIVE, METHOD OF PRODUCING SAME AND ANTICANCER DRUG COMPOSITION CONTAINING SAME". Paragraph 0089; 0090; 0091; 0092; 0093; 0094. . Retrieved 2015/07/15.