(2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

Base Information

Chemical Name:(2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester
CAS No.:944559-52-8
Molecular Formula:C₃₆H₅₅N₅O₆S
Molecular Weight:685.929
Hs Code.:

(2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

Synonyms:(2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

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Chemical Property of (2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

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Technology Process of (2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

There total 22 articles about (2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4-{[2-(3-amino-1-hydroxy-4-methyl-pentyl)-thiazole-4-carbonyl]-amino}-2-methyl-5-phenyl-pentanoic acid methyl ester

: N-methyl-(D)-pipecolinyl-(L)-isoleucine

: 944559-52-8
(2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In ethyl acetate; at 20 ℃; for 8h;
DOI:10.1002/anie.200604557

Reference yield:

: C₂₉H₄₄N₄O₅S*C₂HF₃O₂

: 41447-17-0
(R)-1-methylpiperidine-2-carboxylic acid

: 944559-52-8
(2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; for 3h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.09.010