41447-17-0

Usage

Uses

Used in Pharmaceutical Industry:
(2R)-1-methyl-2-Piperidinecarboxylic acid is used as a chemical reagent for the synthesis of tubulysin derivatives. It plays a significant role in the preparation of tubulysin-U analogues, which are known for their cytotoxic properties. These analogues have potential applications in the development of anticancer drugs, targeting cancer cells and inhibiting their growth.
In the synthesis of other bioactive molecules:
Due to its unique structure and reactivity, (2R)-1-methyl-2-Piperidinecarboxylic acid can be utilized in the development of other pharmaceutical compounds with diverse therapeutic applications. Its chiral nature allows for the creation of enantiomerically pure molecules, which is essential for ensuring the desired biological activity and minimizing potential side effects.
Used in Research and Development:
(2R)-1-methyl-2-Piperidinecarboxylic acid is also employed as a research tool in the field of medicinal chemistry. It helps scientists understand the structure-activity relationships of various biologically active molecules and aids in the design and optimization of new drug candidates.

Upstream product

• 626-67-5 N-methylcyclohexylamine 
• 124-38-9 carbon dioxide 
• 30727-18-5 ethyl 1-methylpiperidine-2-carboxylate 

Downstream Products

• 101353-77-9 1-methyl-piperidine-2-carboxylic acid-(N-ethyl-anilide) 
• 110154-90-0 1-methyl-piperidine-2-carboxylic acid-(4-butoxy-2-methyl-anilide) 
• 113061-48-6 1-methyl-piperidine-2-carboxylic acid-(4-butoxy-2,6-dimethyl-anilide) 
• 108239-53-8 1-methyl-piperidine-2-carboxylic acid benzylamide 
• 20845-34-5 (1-methyl-piperidin-2-yl)-methanol 
• 945423-49-4 1-methyl-piperidine-2-carboxylic acid (2'-methyl-5'-oxazol-2-yl-biphenyl-4-yl)-amide 
• 1123512-46-8 N-(5-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)-2-methylphenyl)-1-methylpiperidine-2-carboxamide 
• 921928-01-0 (R)-perfluorophenyl 1-methylpiperidine-2-carboxylate 
• 58754-48-6 encainide 
• 68474-13-5 (R)-(+)-1-Methyl-2-piperidinemethanol 
• 919518-56-2 4-nitrophenyl N-{[(2R)-1-methylpiperidin-2-yl]carbonyl}-L-isoleucinate 
• 919518-62-0 methyl (2S,4R)-4-[({2-[(1R,3R)-1-acetoxy-4-methyl-3-{[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)pentanoyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-2-methyl-5-phenylpentanoate 
• 936691-45-1 (2S,4R)-allyl 4-(2-((1R,3R)-1-acetoxy-3-((2S,3S)-N,3-dimethyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate 
• 944559-52-8 (2S,4R)-4-{[2-(1R,3R)-(1-hydroxy-4-methyl-3-{(2R)-N-[(1-methylpiperidine-2-carbonyl)-L-isoleucyl]pentanoylamino}pentyl)thiazole-4-carbonyl]amino}-2-methyl-5-phenylpentanoic acid methyl ester 

Relevant academic research and scientific papers

Photolysis of Tertiary Amines in the Presence of CO2: The Paths to Formic Acid, α-Amino Acids, and 1,2-Diamines

The photolysis of triethylamine (1a) in the presence of carbon dioxide leads to the hydrogenation of CO2, the α-C-C coupling of 1a, and the CO2 insertion into the α-C-H σ-bond of amine 1a. This reaction is proposed to proceed through the radical ion pair [R3N?+·CO2?-] generated by the photoionization of amine 1a and the electron capture by CO2. The presence of lithium tetrafluoroborate in the reaction medium promotes the efficient and stereoselective α-C-C coupling of 1a by enhancing the production of α-dialkylamino radicals and the isomerization of N,N,N′,N′-tetraethylbutane-2,3-diamine (4a).

Mechanism of elimination of amino acid derivatives in the gas phase. Pyrolysis kinetics of ethyl picolinate, ethyl 1-methylpipecolinate and picolinic acid

The kinetics of the gas-phase elimination of the title compounds were determined in a static reaction system over the temperature range 180.8-419.4 °C and the pressure range 15-86 Torr (1 Torr = 133.3 Pa). The reactions are homogeneous and unimolecular and obey a first-order rate law. The observed rate coefficients are represented by the following Arrhenius equations: for ethyl picolinate, log[k1(s-1)] = (11.30 ± 0.24) -(180.9 ± 3.0) Kj mol-1 (2.303 RT)-1, for ethyl 1-methylpipecolinate, log[k1(s-1)] = (13.36 ± 0.31) -(209.5 ± 3.9) Kj mol-1 (2.303 RT)-1 and for picolinic acid, log[k1(s-1)] = (12.05 ± 0.10) -(135.7 ± 0.9) Kj mol-1 (2.303 RT)-1. The data from this work together with those reported in the literature confirm previous considerations that amino acids or α-nitrogen substituents of carboxylic acids undergo an extremely rapid decarboxylation process. The pyrolysis kinetics of picolinic acid, which is an intermediate of ethyl picolinate elimination, showed a dramatic fast decomposition into pyridine and CO2 gas. The decarboxylation process of α-amino or α-nitrogen substituents of carboxylic acids differs from the decarboxylation elimination of several known α-substituted carboxylic acids in the gas phase. Copyright