4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

Base Information

Chemical Name:4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline
CAS No.:1206774-17-5
Molecular Formula:C₂₅H₃₀N₂O₂
Molecular Weight:390.525
Hs Code.:

Synonyms:4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

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Chemical Property of 4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

Chemical Property:

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Technology Process of 4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

There total 6 articles about 4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206776-61-5
3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

: 2767-70-6
(p-nitrobenzyl)triphenylphosphonium bromide

: 1206774-17-5
4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

Guidance literature:: With hydrogenchloride; NaH; Pd(OH)2; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 1206774-17-5
4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

4: sodium hydride; 15-crown-5 / mineral oil; tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

5: 20% palladium hydroxide-activated charcoal; hydrogen / methanol; ethyl acetate / 18 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 15-crown-5; 20% palladium hydroxide-activated charcoal; hydrogen; bromine; sodium hydride; sodium carbonate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil; 3: |Suzuki Coupling;
DOI:10.1021/jm401266k

Reference yield:

: 417715-87-8
5-bromo-3-tert-butyl-2-methoxybenzaldehyde

: 1206774-17-5
4-[2-[3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)phenyl]ethyl]aniline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

2: sodium hydride; 15-crown-5 / mineral oil; tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

3: 20% palladium hydroxide-activated charcoal; hydrogen / methanol; ethyl acetate / 18 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 15-crown-5; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; mineral oil; 1: |Suzuki Coupling;
DOI:10.1021/jm401266k