3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

Base Information

Chemical Name:3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine
CAS No.:1206776-61-5
Molecular Formula:C₂₅H₂₆N₂O₄
Molecular Weight:418.492
Hs Code.:

Synonyms:3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

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Chemical Property of 3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

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Technology Process of 3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

There total 4 articles about 3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1206776-46-6
3-tert-butyl-2-methoxy-5-(2-methoxy-3-pyridyl)benzaldehyde

: 1754-42-3
para-nitro-phenylphosphonate diethylique

: 1206776-61-5
3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

Guidance literature:: With 15-crown-5; sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 19h; Inert atmosphere;
DOI:10.1021/jm401266k

Reference yield:

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 1206776-61-5
3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

4: sodium hydride; 15-crown-5 / mineral oil; tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 15-crown-5; bromine; sodium hydride; sodium carbonate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 3: |Suzuki Coupling;
DOI:10.1021/jm401266k

Reference yield:

: 417715-87-8
5-bromo-3-tert-butyl-2-methoxybenzaldehyde

: 1206776-61-5
3-[3-tert-butyl-4-methoxy-5-[(E)-2-(4-nitrophenyl)vinyl]phenyl]-2-methoxypyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / dichloromethane; methanol / 0.5 h / 115 °C / Inert atmosphere; Microwave irradiation

2: sodium hydride; 15-crown-5 / mineral oil; tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 15-crown-5; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; mineral oil; 1: |Suzuki Coupling;
DOI:10.1021/jm401266k