O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

Base Information

Chemical Name:O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite
CAS No.:355127-50-3
Molecular Formula:C₃₇H₄₈N₅O₅PS
Molecular Weight:705.858
Hs Code.:

Synonyms:O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

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Chemical Property of O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

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Technology Process of O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

There total 6 articles about O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 355127-57-0
N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropanol

: 355127-50-3
O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(00)00339-4

Reference yield:

: 34914-36-8
2-(triphenylmethylthio)ethanoic acid

: 355127-50-3
O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / N-hydroxybenzotriazole; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; N,N-diisopropylethylamine / CH₂Cl₂ / 3 h / 20 °C

2: 77 percent / tetrabutylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

3: 52 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / 20 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(00)00339-4

Reference yield:

: 76-83-5
trityl chloride

: 355127-50-3
O-(N-(S-trityl-2-mercaptoacetyl-glycyl-glycyl)-3-aminopropyl)-O'-2-cyanoethyl-N',N'-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / triethylamine / toluene / 3 h

2: 84 percent / N-hydroxybenzotriazole; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆; N,N-diisopropylethylamine / CH₂Cl₂ / 3 h / 20 °C

3: 77 percent / tetrabutylammonium fluoride / tetrahydrofuran / 6 h / 20 °C

4: 52 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1 h / 20 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0968-0896(00)00339-4