Technology Process of benzyl 6-azido-8-(3-chlorophenyl)-5-oxo-2,3,5,6-tetrahydro-1H-[1,4]diazepino[1,7,6-de]quinoxaline-1-carboxylate
There total 7 articles about benzyl 6-azido-8-(3-chlorophenyl)-5-oxo-2,3,5,6-tetrahydro-1H-[1,4]diazepino[1,7,6-de]quinoxaline-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzyl 8-(3-chlorophenyl)-5-oxo-2,3,5,6-tetrahydro-1H-[1,4]diazepino[1,7,6-de]quinoxaline-1-carboxylate;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
2,4,6-Triisopropylbenzenesulfonyl azide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
acetic acid;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 80 °C
2.1: boron trichloride; aluminum (III) chloride / dichloromethane; toluene / 8 h / 0 - 110 °C
2.2: 3 h / 110 °C
3.1: pyridine / dichloromethane / 3 h / 0 - 20 °C
4.1: pyridine / dichloromethane / 3 h / 0 °C
5.1: ammonia / methanol / 16 h / 20 °C
6.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
6.2: 1 h / -78 °C
6.3: 16 h / -78 - 20 °C
With
pyridine; aluminum (III) chloride; lithium aluminium tetrahydride; ammonia; boron trichloride; potassium hexamethylsilazane;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / N,N-dimethyl-formamide / 36 h / 120 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 80 °C
3.1: boron trichloride; aluminum (III) chloride / dichloromethane; toluene / 8 h / 0 - 110 °C
3.2: 3 h / 110 °C
4.1: pyridine / dichloromethane / 3 h / 0 - 20 °C
5.1: pyridine / dichloromethane / 3 h / 0 °C
6.1: ammonia / methanol / 16 h / 20 °C
7.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
7.2: 1 h / -78 °C
7.3: 16 h / -78 - 20 °C
With
pyridine; aluminum (III) chloride; lithium aluminium tetrahydride; ammonia; boron trichloride; potassium hexamethylsilazane; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
![benzyl 8-(3-chlorophenyl)-5-oxo-2,3,5,6-tetrahydro-1H-[1,4]diazepino[1,7,6-de]quinoxaline-1-carboxylate](/Databaselist/images/loading.webp)
