3,4-DIHYDRO-1H-QUINOXALIN-2-ONE

Base Information

• Chemical Name: 3,4-DIHYDRO-1H-QUINOXALIN-2-ONE
• CAS No.: 59564-59-9
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Hs Code.: 2933998090
• Mol file: 59564-59-9.mol

Synonyms:2-Quinoxalinol, 3,4-dihydro-;3,4-Dihydroquinoxalin-2(1H)-one;3,4-Dihydroquinoxalin-2-ol;1,3,4-Trihydroquinoxalin-2-one;3,4-Dihydro-1h-quinoxalin-2-one;3,4-Dihydro-2(1H)-quinoxalinone;

Chemical Property of 3,4-DIHYDRO-1H-QUINOXALIN-2-ONE

Chemical Property:

• Vapor Pressure: 1.1E-05mmHg at 25°C
• Melting Point: 140-143℃
• Refractive Index: 1.564
• Boiling Point: 370.5 °C at 760 mmHg
• PKA: 13.24±0.20(Predicted)
• Flash Point: 183.4 °C
• PSA: 41.13000
• Density: 1.186 g/cm³
• LogP: 1.32660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

3,4-Dihydro-1H-quinoxalin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DIHYDRO-1H-QUINOXALIN-2-ONE

There total 3 articles about 3,4-DIHYDRO-1H-QUINOXALIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

diazoacetic acid ethyl ester (623-73-4) + 1,2-diamino-benzene (95-54-5) → C10H14N2O2 (1179880-63-7) + 1,2,3,4-tetrahydroquinoxalin-2-one (59564-59-9)

Guidance literature:

With meso-tetraphenylporphyrin iron(III) chloride; In dichloromethane; at 22 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1142/S1088424610001982

Reference yield:

5,12-dihydro-5,12-diacetylquinoxalino<2,3-b>quinoxaline (65182-17-4) → N,N'-(o-phenylene)di(acetamide) (2050-85-3) + 1,2,3,4-tetrahydroquinoxalin-2-one (59564-59-9)

Guidance literature:

With sulfuric acid; In acetonitrile; at 20 ℃; electrolysis;

DOI:10.1139/v82-402

Reference yield:

chloroacetic acid (79-11-8) + 1,2-diamino-benzene (95-54-5) → 1-carboxymethyl-1,2,3,4-tetrahydroquinoxaline-3-one (80310-02-7) + 1,2,3,4-tetrahydroquinoxalin-2-one (59564-59-9)

Guidance literature:

With sodium carbonate; In water; for 4h; Heating;

upstream raw materials:

5,12-dihydro-5,12-diacetylquinoxalino<2,3-b>quinoxaline

chloroacetic acid

1,2-diamino-benzene

diazoacetic acid ethyl ester

Downstream raw materials:

4-ethyl-1,2,3,4-tetrahydroquinoxalinone-2

4-propyl-3,4-dihydro-1H-quinoxalin-2-one

1-carboxymethyl-1,2,3,4-tetrahydroquinoxaline-3-one

quinoxaline-2,3-dione