11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost

Base Information

• Chemical Name: 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost
• CAS No.: 1393740-71-0
• Molecular Formula: C₄₁H₇₁NO₅Si₂
• Molecular Weight: 714.189
• Mol file: 1393740-71-0.mol

Synonyms:11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost

Chemical Property of 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost

There total 3 articles about 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Z)-7-((1R,2R,3R,5S)-3-(tert-butyldimethylsilyloxy)-2-((S,E)-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-enyl)-5-hydroxycyclopentyl)-N-ethylhept-5-enamide (1240483-19-5) + isobutyryl chloride (79-30-1) → 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost (1393740-71-0)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 16h;

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost (1393740-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: pyridine / 16 h / 0 - 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

Reference yield:

bimatoprost (155206-00-1) → 11,15-di-tert-butyldimethylsilyloxy-9-isobutyryl-bimatoprost (1393740-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: pyridine / 16 h / 0 - 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

upstream raw materials:

tert-butyldimethylsilyl chloride

(Z)-7-((1R,2R,3R,5S)-3-(tert-butyldimethylsilyloxy)-2-((S,E)-3-(tert-butyldimethylsilyloxy)-5-phenylpent-1-enyl)-5-hydroxycyclopentyl)-N-ethylhept-5-enamide

isobutyryl chloride

bimatoprost

Downstream raw materials:

9-isobutyryl-bimatoprost