3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde

Base Information

• Chemical Name: 3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde
• CAS No.: 350997-67-0
• Molecular Formula: C10H7ClN2O
• Molecular Weight: 206.631
• Hs Code.: 2933199090
• Mol file: 350997-67-0.mol

Synonyms:3-(4-Chlorophenyl)-1H-pyrazole-4-carbaldehyde;1H-Pyrazole-4-carboxaldehyde,3-(4-chlorophenyl)-;3-(4-Chlorophenyl)pyrazole-4-carbaldehyde;5-(4-Chlorophenyl)-1H-pyrazole-4-carbaldehyde;Pyrazole-4-carboxaldehyde, 3-(4-chlorophenyl)-;

Chemical Property of 3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde

Chemical Property:

• Melting Point: 142-144 °C(Solv: water (7732-18-5))
• Boiling Point: 445.021 °C at 760 mmHg
• PKA: 10.45±0.50(Predicted)
• Flash Point: 222.941 °C
• PSA: 45.75000
• Density: 1.379 g/cm³
• LogP: 2.54260
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Chlorophenyl)-1H-pyrazole-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde

There total 5 articles about 3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

p-chloroacetophenone semicarbazone (7575-74-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde (350997-67-0) + 3-(4-chlorophenyl)-1H-pyrazole (59843-58-2)

Guidance literature:

With trichlorophosphate; at 40 - 80 ℃;

DOI:10.1007/s11176-005-0318-7

Reference yield:

p-chloroacetophenone semicarbazone (7575-74-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde (350997-67-0)

Guidance literature:

p-chloroacetophenone semicarbazone; N,N-dimethyl-formamide; With trichlorophosphate;

With sodium hydroxide; water;

DOI:10.1016/j.bmcl.2008.08.058

Reference yield:

p-chloroacetophenone semicarbazone (7575-74-8) → 3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde (350997-67-0)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 0 - 70 ℃; for 6.5h;

DOI:10.2174/1573406412666160822160156

upstream raw materials:

p-chloroacetophenone semicarbazone

N,N-dimethyl-formamide

para-chloroacetophenone

C₉H₁₀ClN₃O

Downstream raw materials:

3-p-chlorophenyl-1H-pyrazole-4-carboxylic acid

dimethyl 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

C₂₀H₁₇ClN₆OS

C₂₀H₁₇ClN₆OS