7575-74-8

Basic information

• Product Name: 2-[1-(4-chlorophenyl)ethylidene]hydrazinecarboxamide
• CAS NO: 7575-74-8
• Molecular Formula: C₉H₁₀ClN₃O
• Molecular Weight: 211.6482
• Mol File: 7575-74-8.mol
• Article Data: 12

Chemical Properties

• Density: 1.31g/cm³
• Refractive Index: 1.596
• CAS DataBase Reference: 2-[1-(4-chlorophenyl)ethylidene]hydrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-chlorophenyl)ethylidene]hydrazinecarboxamide(7575-74-8)
• EPA Substance Registry System: 2-[1-(4-chlorophenyl)ethylidene]hydrazinecarboxamide(7575-74-8)

Safety Data

• Hazardous Substances Data: 7575-74-8(Hazardous Substances Data)

Usage

General Description

2-[1-(4-chlorophenyl)ethylidene]hydrazinecarboxamide is an organic chemical compound with the molecular formula C9H10ClN3O. It is a hydrazinecarboxamide derivative with a 4-chlorophenyl group attached to the ethylidene hydrazine moiety. 2-[1-(4-chlorophenyl)ethylidene]hydrazinecarboxamide has been studied for its potential pharmacological activities, including its anti-inflammatory and anti-cancer properties. Its structural features make it a potential candidate for the development of new drugs and pharmaceuticals. However, further research is needed to fully understand its biological and pharmacological effects.

Upstream product

• 67471-39-0 1-(p-chlorophenyl)-1-methoxyethene 
• 563-41-7 semicarbazide hydrochloride 
• 99-91-2 para-chloroacetophenone 
• 4426-72-6 hydrazine carboxamide 
• 83739-62-2 2-bromo-1-methoxy-1-(4-chlorophenyl)ethane 

Downstream Products

• 27892-68-8 4-(4-chlorophenyl)-[1,2,3]-selenadiazole 
• 71864-67-0 5-(4-chloro-phenyl)-5-methyl-5H-[1,3,4]oxadiazol-2-one 
• 350997-67-0 3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 57444-38-9 Potassium; (4-chloro-phenyl)-ethyneselenolate 
• 135641-91-7 3-p-chlorophenyl-1H-pyrazole-4-carboxylic acid 
• 59843-58-2 3-(4-chlorophenyl)-1H-pyrazole 
• 99-91-2 para-chloroacetophenone 

Relevant articles and documents

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties. Biological evaluation indicated t

Synthesis and biological evaluation of some pyrazole derivatives, containing (Thio) semicarbazide, as dual anti-inflammatory antimicrobial agents

Background: Several series of pyrazole derivatives containing (thio) semicarbazide (4a-4h, 5a-5l, 6a-6f, 7a-7c) were designed and synthesized to screen dual inflammatory and antimicrobial activities. Methods: The products were characterized by1

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.