5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

Base Information

Chemical Name:5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate
CAS No.:691880-73-6
Molecular Formula:C₃₁H₃₄N₃O₇PS
Molecular Weight:623.667
Hs Code.:

Synonyms:5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

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Chemical Property of 5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

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Technology Process of 5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

There total 4 articles about 5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 691880-72-5
5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine

: 691880-73-6
5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

Guidance literature:: With pyridine; phosphonic Acid; pivaloyl chloride;
DOI:10.1080/10426500490257113

Reference yield:

: 51549-29-2
2'-deoxy-3',5'-bis-O-(tert-butyldimethylsilyl)cytidine

: 691880-73-6
5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic anhydride / CH₂Cl₂ / -65 - -55 °C

1.2: 62 percent / CH₂Cl₂ / 1 h / -45 °C

2.1: 70 percent / Et₃N*3HF / tetrahydrofuran / 16 h

3.1: 49 percent / pyridine

4.1: 56 percent / phosphorous acid; pivaloyl chloride; pyridine

With pyridine; phosphonic Acid; pivaloyl chloride; triethylamine tris(hydrogen fluoride); trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1080/10426500490257113

Reference yield:

: 691880-67-8
C₂₃H₄₅N₃O₄SSi₂

: 691880-73-6
5'-O-monomethoxytrityl-2'-deoxycytidine dimethylsulfilimine 3'-H-phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / Et₃N*3HF / tetrahydrofuran / 16 h

2: 49 percent / pyridine

3: 56 percent / phosphorous acid; pivaloyl chloride; pyridine

With pyridine; phosphonic Acid; pivaloyl chloride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;
DOI:10.1080/10426500490257113