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51549-29-2

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51549-29-2 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 51549-29-2 differently. You can refer to the following data:
1. 2'',3''-Di-O-(tert-butyldimethylsilyl)-2''-deoxycytidine is an intermediate for biosynthesis of cholyl-CoA and oligodeoxyribonucleotides.
2. 2',3'-Di-O-(tert-butyldimethylsilyl)-2'-deoxycytidine is an intermediate for biosynthesis of cholyl-CoA and oligodeoxyribonucleotides.

Check Digit Verification of cas no

The CAS Registry Mumber 51549-29-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,4 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 51549-29:
(7*5)+(6*1)+(5*5)+(4*4)+(3*9)+(2*2)+(1*9)=122
122 % 10 = 2
So 51549-29-2 is a valid CAS Registry Number.

51549-29-2Relevant articles and documents

Biomimetic Iron Complex Achieves TET Enzyme Reactivity**

Carell, Thomas,Daumann, Lena J.,Jonasson, Niko S. W.,Korytiaková, Eva,Schmidl, David

supporting information, p. 21457 - 21463 (2021/08/23)

The epigenetic marker 5-methyl-2′-deoxycytidine (5mdC) is the most prevalent modification to DNA. It is removed inter alia via an active demethylation pathway: oxidation by Ten-Eleven Translocation 5-methyl cytosine dioxygenase (TET) and subsequent removal via base excision repair or direct demodification. Recently, we have shown that the synthetic iron(IV)-oxo complex [FeIV(O)(Py5Me2H)]2+ (1) can serve as a biomimetic model for TET by oxidizing the nucleobase 5-methyl cytosine (5mC) to its natural metabolites. In this work, we demonstrate that nucleosides and even short oligonucleotide strands can also serve as substrates, using a range of HPLC and MS techniques. We found that the 5-position of 5mC is oxidized preferably by 1, with side reactions occurring only at the strand ends of the used oligonucleotides. A detailed study of the reactivity of 1 towards nucleosides confirms our results; that oxidation of the anomeric center (1′) is the most common side reaction.

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