2-aMino-4,7-dihydro-4-oxo-3H-Pyrrolo[2,3-d]pyriMidine-6-acetic acid

Base Information

• Chemical Name: 2-aMino-4,7-dihydro-4-oxo-3H-Pyrrolo[2,3-d]pyriMidine-6-acetic acid
• CAS No.: 351185-23-4
• Molecular Formula: C₈H₈N₄O₃
• Molecular Weight: 208.177
• Mol file: 351185-23-4.mol

Synonyms:2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid

Chemical Property of 2-aMino-4,7-dihydro-4-oxo-3H-Pyrrolo[2,3-d]pyriMidine-6-acetic acid

Chemical Property:

Purity/Quality:

2-amino-4,7-dihydro-4-oxo-3H-Pyrrolo[2,3-d]pyrimidine-6-aceticacid 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-aMino-4,7-dihydro-4-oxo-3H-Pyrrolo[2,3-d]pyriMidine-6-acetic acid

There total 5 articles about 2-aMino-4,7-dihydro-4-oxo-3H-Pyrrolo[2,3-d]pyriMidine-6-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid ethyl ester (67226-39-5) → 2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid (351185-23-4)

Guidance literature:

With sodium hydroxide; water; In ethanol; at 90 ℃; for 2h;

DOI:10.1039/b817733n

Reference yield:

2-amino-6-(2-hydroxyethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one → 2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid (351185-23-4)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 20 ℃; Cooling with ice;

Reference yield:

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (7355-55-7) → 2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid (351185-23-4)

Guidance literature:

Multi-step reaction with 4 steps

1: iodine / water; ethanol / 2 h / Reflux

2: palladium dichloride; triphenylphosphine; triethylamine; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 - 100 °C

3: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C / 2585.81 Torr

4: chromium(VI) oxide; sulfuric acid / water; acetone / 20 °C / Cooling with ice

With chromium(VI) oxide; copper(l) iodide; sulfuric acid; 5%-palladium/activated carbon; hydrogen; iodine; triethylamine; triphenylphosphine; palladium dichloride; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)acetic acid ethyl ester

2-amino-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Downstream raw materials:

8-{[3,5-bis(3,5-di-tert-butylbenzyloxy)benzylcarbamoyl]methyl}-7-deazaguanine