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1-(2-Cyanophenyl)piperazine

Base Information Edit
  • Chemical Name:1-(2-Cyanophenyl)piperazine
  • CAS No.:111373-03-6
  • Molecular Formula:C11H13N3
  • Molecular Weight:187.244
  • Hs Code.:2933599090
  • European Community (EC) Number:626-613-9
  • UNII:LYK8UDP7Q4
  • DSSTox Substance ID:DTXSID20370994
  • Nikkaji Number:J837.493G
  • Wikidata:Q72458914
  • ChEMBL ID:CHEMBL275943
  • Mol file:111373-03-6.mol
1-(2-Cyanophenyl)piperazine

Synonyms:1-(2-Cyanophenyl)piperazine;111373-03-6;2-(piperazin-1-yl)benzonitrile;2-piperazin-1-ylbenzonitrile;Benzonitrile, 2-(1-piperazinyl)-;2-Piperazinobenzonitrile;2-(1-piperazinyl)benzonitrile;2-(1-Piperazino)benzonitrile;2-Piperazin-1-yl-benzonitrile;2-piperazinylbenzenecarbonitrile;LYK8UDP7Q4;n-(2-cyanophenyl)piperazine;1-(2-Cyanophenyl)-piperazine;2-Piperazin-1-ylbenzenecarbonitrile;UNII-LYK8UDP7Q4;MFCD00040793;CHEMBL275943;D02YFZ;(2-cyano-phenyl)-piperazine;SCHEMBL233169;1-(2-cyanophenyl) piperazine;4-(2-cyano-phenyl)-piperazine;FRICBZWJFIRJOB-UHFFFAOYSA-;DTXSID20370994;FRICBZWJFIRJOB-UHFFFAOYSA-N;AMY23146;1-(2-Cyanophenyl)piperazine, 99%;BDBM50017458;STK503781;AKOS000261428;AC-2601;FS-1228;PD180699;SY002315;FT-0605532;P2448;EN300-62676;Z335292446;InChI=1/C11H13N3/c12-9-10-3-1-2-4-11(10)14-7-5-13-6-8-14/h1-4,13H,5-8H2

Suppliers and Price of 1-(2-Cyanophenyl)piperazine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 1-(2-Cyanophenyl)piperazine
  • 100mg
  • $ 45.00
  • TCI Chemical
  • 2-(1-Piperazinyl)benzonitrile >98.0%(GC)(T)
  • 5g
  • $ 51.00
  • SynQuest Laboratories
  • 1-(2-Cyanophenyl)piperazine 98%
  • 100 g
  • $ 1036.00
  • SynQuest Laboratories
  • 1-(2-Cyanophenyl)piperazine 98%
  • 25 g
  • $ 336.00
  • SynQuest Laboratories
  • 1-(2-Cyanophenyl)piperazine 98%
  • 5 g
  • $ 108.00
  • Sigma-Aldrich
  • 1-(2-Cyanophenyl)piperazine 99%
  • 5g
  • $ 71.00
  • Matrix Scientific
  • 2-Piperazin-1-ylbenzonitrile
  • 500mg
  • $ 10.00
  • CHESS?
  • 1-(2-Cyanophenyl)-piperazine >98
  • 25 g
  • $ 12000.00
  • CHESS?
  • 1-(2-Cyanophenyl)-piperazine >98
  • 5 g
  • $ 6000.00
  • Chem-Impex
  • 2-(1-Piperazinyl)benzonitrile,≥98%(GC)Hazmat ≥98%(GC)
  • 5G
  • $ 56.62
Total 47 raw suppliers
Chemical Property of 1-(2-Cyanophenyl)piperazine Edit
Chemical Property:
  • Appearance/Colour:White solid 
  • Vapor Pressure:1.19E-05mmHg at 25°C 
  • Melting Point:113-115 °C 
  • Refractive Index:n20/D 1.5890(lit.)  
  • Boiling Point:369.441 °C at 760 mmHg 
  • PKA:8.77±0.10(Predicted) 
  • Flash Point:177.232 °C 
  • PSA:39.06000 
  • Density:1.161 g/cm3 
  • LogP:1.36168 
  • Sensitive.:Moisture Sensitive 
  • XLogP3:1.1
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:1
  • Exact Mass:187.110947427
  • Heavy Atom Count:14
  • Complexity:224
Purity/Quality:

97% *data from raw suppliers

1-(2-Cyanophenyl)piperazine *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 10-36 
  • Safety Statements: 16-24/25-36 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1CN(CCN1)C2=CC=CC=C2C#N
  • Uses 1-(2-cyanophenyl)piperazine is used in the synthesis of melanocortin subtype-4 receptor (MC4R) agonists. MC4R is located in the hypothalamus and helps to regulate metabolism, feeding and reproductive behavior. Agonists to these receptors have shown to decrease feeding behaviors.
Technology Process of 1-(2-Cyanophenyl)piperazine

There total 9 articles about 1-(2-Cyanophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 0.166667h; Temperature;
DOI:10.1021/acs.orglett.6b02591
Guidance literature:
With tetrabutylammomium bromide; copper(II) acetate monohydrate; In water; at 20 - 140 ℃; Microwave irradiation;
DOI:10.1016/j.tetlet.2009.05.073
Guidance literature:
With tetrabutylammomium bromide; copper(II) acetate monohydrate; potassium iodide; N,N`-dimethylethylenediamine; In water; at 20 - 140 ℃; Microwave irradiation;
DOI:10.1016/j.tetlet.2009.05.073
Refernces Edit
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