1011-13-8

Basic information

• Product Name: 1-(2-BROMOPHENYL)PIPERAZINE
• Synonyms: 1-(2-BROMOPHENYL)PIPERAZINE;1-(2-BROMOPHENYL)-PIPERAZINE >97%;Vortioxetine Impurity 13;Vortioxetine impurity B;1- (2- bromine phenyl) piperazine
• CAS NO: 1011-13-8
• Molecular Formula: C₁₀H₁₃BrN₂
• Molecular Weight: 241.13
• EINECS: 1312995-182-4
• Product Categories: Piperaizine;piperazines
• Mol File: 1011-13-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 94-96°C/0.02mm
• Flash Point: 157.592 °C
• Appearance: Gray power
• Density: 1.386 g/cm³
• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.575
• PKA: 8.80±0.10(Predicted)
• CAS DataBase Reference: 1-(2-BROMOPHENYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOPHENYL)PIPERAZINE(1011-13-8)
• EPA Substance Registry System: 1-(2-BROMOPHENYL)PIPERAZINE(1011-13-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1011-13-8(Hazardous Substances Data)

Usage

Description

1-(2-Bromophenyl)piperazine, also known as 2-(1-piperazinyl)bromobenzene, is a chemical compound with the molecular formula C10H13BrN2. It is a derivative of piperazine and contains a bromine atom attached to a phenyl ring. 1-(2-Bromophenyl)piperazine is recognized for its potential applications in the pharmaceutical industry, particularly in the synthesis of antidepressants and antipsychotics, as well as its research potential in neurochemistry and drug development.

Uses

Used in Pharmaceutical Synthesis:
1-(2-Bromophenyl)piperazine is used as an intermediate in the synthesis of various pharmaceuticals, specifically for the development of antidepressants and antipsychotics. Its unique chemical structure allows it to be a key component in creating medications that address mental health conditions.
Used in Neurochemistry Research:
1-(2-Bromophenyl)piperazine is used as a serotonin receptor antagonist in neurochemistry research. Its interaction with serotonin receptors is of interest to scientists studying the role of these receptors in mood regulation and other neurological processes.
Used in Drug Development:
In the field of drug development, 1-(2-Bromophenyl)piperazine is utilized for its potential in creating new medications. Its properties are being investigated to understand its biological and pharmacological effects, which could lead to advancements in treating neurological disorders.
Used in Treatment of Neurological Disorders:
Although further research is necessary, 1-(2-Bromophenyl)piperazine has been investigated for its potential use in the treatment of various neurological disorders. Its role as a serotonin receptor antagonist suggests it may have therapeutic applications in conditions related to neurotransmitter imbalances.

InChI:InChI=1/C10H13BrN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 853745-55-8 1-(2-bromophenyl)piperazine hydrochloride 
• 50606-33-2 piperazine-1-carboxylic acid phenyl ester 
• 75-65-0 tert-butyl alcohol 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 615-36-1 2-bromoaniline 
• 110-85-0 piperazine 
• 137092-17-2 2-Bromo-benzenediazonium; hydrogen sulfate 
• 494773-35-2 4-(2-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 1616296-14-0 4-(4-(2-bromophenyl)piperazin-1-yl)-2-cyclopropylquinazolin-6-amine 
• 1616296-13-9 4-(4-(2-bromophenyl)piperazin-1-yl)-2-cyclopropyl-6-nitroquinazoline 
• 508233-74-7 vortioxetine 
• 100379-99-5 3-[4-(2-bromo-phenyl)-piperazino]-propionitrile 

Relevant articles and documents

Application of heterocyclic substituted phenylpiperazine (Phenylpiperidine) derivative in antidepressant drug

The invention discloses application of a heterocyclic substituted phenylpiperazine (Phenylpiperidine ) derivative in an antidepressant drug, and the compound provided by the invention has good inhibitory activity on 5-HT reuptake, 5-HT1A and 5-HT7 recepto

Preparation method of vortioxetine

The invention relates to the field of medicines, in particular to a preparation method of vortioxetine. The preparation method comprises the steps that 2-bromoiodobenzene, N-phenoxycarbonyl piperazineand tert butyl alcohol are subjected to condensation to form an intermediate 1, that is a mixture of 4-(2-bromine phenyl) piperazine-1-tertiary butyl carboxylate and 1-(2-bromine phenyl) piperazine;the intermediate 1 and 2,4-dimethyl phenylthiophenol are subjected to condensation to form an intermediate 2, that is a mixture of N-Boc-vortioxetine and vortioxetine; the N-Boc-vortioxetine in the intermediate 2 is subjected to Boc protecting group removal, and then a crude vortioxetine product is formed through alkalization, and the crude vortioxetine product is subjected to salinization, purification and alkaline dissociation to obtain the vortioxetine. The method has the advantages that the raw materials are simple and easy to obtain, the product has high yield and high purity, and the method is suitable for industrial production.

Method for preparing vortioxetine

The invention discloses a method for preparing vortioxetine. The preparation method comprises the following steps: enabling 2-bromobenzenamine to react with sodium nitrite so as to obtain a reactive intermediate in the presence of concentrated sulfuric acid; carrying out a reaction with piperazine to obtain an intermediate A, performing alkali regulation on the intermediate A, and synthesizing with 2,4-dimethylthiophenol, thereby obtaining the target product vortioxetine. The method is short in synthetic route, simple in process, high in product yield, and suitable for industrialized production. The structural formula is as shown in the specification.