N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine
• CAS No.: 1101872-55-2
• Molecular Formula: C₂₃H₃₁NO₇S
• Molecular Weight: 465.568
• Mol file: 1101872-55-2.mol

Synonyms:N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine

Chemical Property of N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine

There total 2 articles about N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

tert-butyl N-[2-(2-hydroxy-5-methoxyphenyl)ethyl]-carbamate (939985-83-8) + bromoethyl-2-benzyl ether (1462-37-9) + p-toluenesulfonyl chloride (98-59-9) → N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine (1101872-55-2)

Guidance literature:

tert-butyl N-[2-(2-hydroxy-5-methoxyphenyl)ethyl]-carbamate; bromoethyl-2-benzyl ether; With potassium carbonate; In acetonitrile; at 80 ℃; for 20h;

With 10% Pd/C; hydrogen; In ethanol; at 20 ℃; for 18h;

p-toluenesulfonyl chloride; With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;

DOI:10.1016/j.bmc.2008.10.048

Reference yield:

N-(tert-butoxycarbonyl)-2-[2-(2-hydroxyethoxy)-5-methoxyphenyl]ethylamine (1101872-53-0) + p-toluenesulfonyl chloride (98-59-9) → N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine (1101872-55-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2010.05.025

Reference yield: 74.0%

N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine (1101872-55-2) + propargyl alcohol (107-19-7) → N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-propargyloxyethoxy)phenyl]ethylamine (1101872-48-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 70 ℃; for 5h;

DOI:10.1016/j.bmc.2008.10.048

upstream raw materials:

tert-butyl N-[2-(2-hydroxy-5-methoxyphenyl)ethyl]-carbamate

bromoethyl-2-benzyl ether

p-toluenesulfonyl chloride

N-(tert-butoxycarbonyl)-2-[2-(2-hydroxyethoxy)-5-methoxyphenyl]ethylamine

Downstream raw materials:

N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-propargyloxyethoxy)phenyl]ethylamine