(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

Base Information

Chemical Name:(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one
CAS No.:181224-95-3
Molecular Formula:C₂₆H₃₁NO₉
Molecular Weight:501.533
Hs Code.:

Synonyms:(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

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Chemical Property of (2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

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Technology Process of (2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

There total 1 articles about (2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 137423-23-5
(2R,3R,4S,4aR)-5-(4-Methoxybenzyl)-2-<(4-methoxybenzyl)oxy>-3,4-bis<(methoxymethyl)oxy>-3,4,4a,5-tetrahydro<1,3>dioxolo<4,5-j>phenanthridin-6(2H)-one

: 181224-95-3
(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; Ambient temperature;
DOI:10.3987/COM-96-7481

Reference yield:

: 181224-95-3
(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

: 181225-12-7
(3R,4S,4aR,11bR)-3,4-Dihydroxy-5-(4-methoxy-benzyl)-3,4a,5,11b-tetrahydro-4H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine; CH₂Cl₂ / 0 °C

2: 18-crown-6 / benzene / Ambient temperature

3: 98 percent / MeONa / methanol / 0 °C

4: pyridine; CH₂Cl₂ / 0 °C

5: DBU

6: 92 percent / 1N aq HCl / tetrahydrofuran / 50 °C

With hydrogenchloride; 18-crown-6 ether; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; pyridine; methanol; dichloromethane; benzene;
DOI:10.3987/COM-96-7481

Reference yield:

: 181224-95-3
(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

: 181225-14-9
C₂₂H₂₁NO₇

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine; CH₂Cl₂ / 0 °C

2: 18-crown-6 / benzene / Ambient temperature

3: 98 percent / MeONa / methanol / 0 °C

4: pyridine; CH₂Cl₂ / 0 °C

5: DBU

6: 92 percent / 1N aq HCl / tetrahydrofuran / 50 °C

7: 46 percent / m-chloroperbenzoic acid, phosphate buffer (pH 8) / CH₂Cl₂ / 50 °C

With hydrogenchloride; phosphate buffer; 18-crown-6 ether; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; dichloromethane; benzene;
DOI:10.3987/COM-96-7481