Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

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Chemical Name:Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester
CAS No.:181224-98-6
Molecular Formula:C₂₇H₃₀F₃NO₁₁S
Molecular Weight:633.597
Hs Code.:

Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

There total 2 articles about Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137423-23-5
(2R,3R,4S,4aR)-5-(4-Methoxybenzyl)-2-<(4-methoxybenzyl)oxy>-3,4-bis<(methoxymethyl)oxy>-3,4,4a,5-tetrahydro<1,3>dioxolo<4,5-j>phenanthridin-6(2H)-one

: 181224-98-6
Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / H₂ / 5percent Pd-C / ethanol; ethyl acetate / Ambient temperature

2: pyridine; CH₂Cl₂ / 0 °C

With hydrogen; palladium on activated charcoal; In pyridine; ethanol; dichloromethane; ethyl acetate;
DOI:10.3987/COM-96-7481

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 181224-95-3
(2R,3R,4S,4aR,11bR)-2-Hydroxy-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-1,3,4,4a,5,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one

: 181224-98-6
Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

Guidance literature:: In pyridine; dichloromethane; at 0 ℃;
DOI:10.3987/COM-96-7481

Reference yield:

: 181224-98-6
Trifluoro-methanesulfonic acid (2R,3S,4S,4aR,11bR)-5-(4-methoxy-benzyl)-3,4-bis-methoxymethoxy-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-2-yl ester

: 181225-16-1
Acetic acid (1R,2S,3S,4S,4aR,11bR)-2,3,4-triacetoxy-5-(4-methoxy-benzyl)-6-oxo-1,2,3,4,4a,5,6,11b-octahydro-[1,3]dioxolo[4,5-j]phenanthridin-1-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 18-crown-6 / benzene / Ambient temperature

2: 98 percent / MeONa / methanol / 0 °C

3: pyridine; CH₂Cl₂ / 0 °C

4: DBU

5: 92 percent / 1N aq HCl / tetrahydrofuran / 50 °C

6: 46 percent / m-chloroperbenzoic acid, phosphate buffer (pH 8) / CH₂Cl₂ / 50 °C

7: 2.) ZnCl₂ / 1.) DMF, H₂O, 60 deg C; 2.) rt

With hydrogenchloride; phosphate buffer; 18-crown-6 ether; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; dichloromethane; benzene;
DOI:10.3987/COM-96-7481