((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-10-yl)-acetonitrile

Base Information

• Chemical Name: ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-10-yl)-acetonitrile
• CAS No.: 125107-72-4
• Molecular Formula: C₁₇H₁₄N₂O₂
• Molecular Weight: 278.31

Synonyms:((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-10-yl)-acetonitrile

Chemical Property of ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-10-yl)-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-10-yl)-acetonitrile

There total 3 articles about ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-10-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

N-phenyl-maleimide (941-69-5) + Bicyclo<2.2.1>hept-5-en-2-on-oxim (65132-85-6) → ((1R,2S,6S,7R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.02,6]dec-8-en-1-yl)-acetonitrile (125107-71-3) + ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.02,6]dec-8-en-10-yl)-acetonitrile (125107-72-4)

Guidance literature:

With boron trifluoride diethyl etherate; In various solvent(s); at 90 ℃;

DOI:10.1016/S0040-4039(00)99316-X

Reference yield:

norborn-5-en-2-one (694-98-4) → ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.02,6]dec-8-en-10-yl)-acetonitrile (125107-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂NOH*HCl, NaOH / ethanol; H₂O / Ambient temperature

2: 14 percent / BF₃*Et₂O / various solvent(s) / 90 °C

With sodium hydroxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; In ethanol; water;

DOI:10.1016/S0040-4039(00)99316-X

Reference yield:

2-chlorobicyclo<2.2.1>hept-5-ene-2-carbonitrile (6945-87-5) → ((1R,2R,6S,7S,10R)-3,5-Dioxo-4-phenyl-4-aza-tricyclo[5.2.1.02,6]dec-8-en-10-yl)-acetonitrile (125107-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / dimethylsulfoxide; H₂O / 85 °C

2: H₂NOH*HCl, NaOH / ethanol; H₂O / Ambient temperature

3: 14 percent / BF₃*Et₂O / various solvent(s) / 90 °C

With potassium hydroxide; sodium hydroxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; In ethanol; water; dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)99316-X

upstream raw materials:

N-phenyl-maleimide

Bicyclo<2.2.1>hept-5-en-2-on-oxim

norborn-5-en-2-one

2-chlorobicyclo<2.2.1>hept-5-ene-2-carbonitrile

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