3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine

Base Information

• Chemical Name: 3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine
• CAS No.: 1099778-81-0
• Molecular Formula: C₁₃H₇ClF₆N₂
• Molecular Weight: 340.655
• Mol file: 1099778-81-0.mol

Synonyms:3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine

Chemical Property of 3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine

There total 2 articles about 3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2,4-bis(trifluoromethyl)-phenyl)-6-methylpyridazine (1000787-77-8) → 3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine (1099778-81-0)

Guidance literature:

With trichloroisocyanuric acid; In 1,2-dichloro-ethane; at 40 - 70 ℃; for 2h;

Reference yield:

3-(2,4-bis(trifluoromethyl)-phenyl)-6-methylpyridazine (1000787-77-8) + trichloroisocyanuric acid (87-90-1) → 3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine (1099778-81-0)

Guidance literature:

In 1,1-dichloroethane;

Reference yield:

3-(2,4-bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine (1099778-81-0) + 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine (89075-43-4) → 5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridazin-3-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine (1000787-75-6)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 8h; Product distribution / selectivity;

upstream raw materials:

3-(2,4-bis(trifluoromethyl)-phenyl)-6-methylpyridazine

trichloroisocyanuric acid

Downstream raw materials:

5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridazin-3-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine

5-[6-(2,4-Bis-trifluoromethyl-phenyl)-pyridazin-3-ylmethyl]-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine