1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

Base Information

Chemical Name:1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)
CAS No.:222318-01-6
Molecular Formula:C₂₀H₂₄ClN₃O₂
Molecular Weight:373.882
Hs Code.:

1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1<i>H</i>,5<i>H</i>-pyrrolo[2,3-<i>c</i>]azepine-4,8-dione 4-(<i>O</i>-benzyl-oxime)

Synonyms:1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

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Chemical Property of 1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

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Technology Process of 1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

There total 4 articles about 1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 136975-57-0
1-(4-Chlorobutyl)-7-methyl-6,7-dihydropyrrolo[2,3-c]azepine-4,8(1H,5H)-dione

: 222318-01-6
1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

Guidance literature:: With sodium acetate; In methanol; for 5h; Heating;
DOI:10.1248/cpb.47.246

Reference yield:

: 137003-97-5
7-methyl-6,7-dihydropyrrolo[2,3-c]-azepine-4,8(1H,5H)-dione

: 222318-01-6
1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / dimethylformamide / 5 h / 80 °C

2: 87 percent / NaOAc / methanol / 5 h / Heating

With sodium acetate; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.246

Reference yield:

: 149109-14-8
3-propionic acid

: 222318-01-6
1-(4-chloro-butyl)-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-benzyl-oxime)

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 80 percent aq. polyphosphoric acid / 0.5 h / 100 °C

2: 97 percent / K₂CO₃ / dimethylformamide / 5 h / 80 °C

3: 87 percent / NaOAc / methanol / 5 h / Heating

With PPA; sodium acetate; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.246