(R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane

Base Information

• Chemical Name: (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane
• CAS No.: 220018-28-0
• Molecular Formula: C₁₈H₂₂O₂S
• Molecular Weight: 302.437
• Mol file: 220018-28-0.mol

Synonyms:(R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane

Chemical Property of (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane

There total 4 articles about (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

thiophenol (108-98-5) + (R)-1-((3-bromo-2-methylpropoxy)methyl)-4-methoxybenzene (220018-27-9) → (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane (220018-28-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; for 2h; Ambient temperature;

DOI:10.1039/a805856c

Reference yield:

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane (220018-28-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hexane; CH₂Cl₂ / 0 °C

2: 98 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

3: 93 percent / NBS, Ph₃P / CH₂Cl₂ / 1 h / Ambient temperature

4: 96 percent / DBU / benzene / 2 h / Ambient temperature

With N-Bromosuccinimide; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In diethyl ether; hexane; dichloromethane; benzene;

DOI:10.1039/a805856c

Reference yield:

(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol (160238-45-9) → (R)-1-(4-Methoxybenzyloxy)-2-methyl-3-phenylthiopropane (220018-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NBS, Ph₃P / CH₂Cl₂ / 1 h / Ambient temperature

2: 96 percent / DBU / benzene / 2 h / Ambient temperature

With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In dichloromethane; benzene;

DOI:10.1039/a805856c

upstream raw materials:

thiophenol

(R)-1-((3-bromo-2-methylpropoxy)methyl)-4-methoxybenzene

O-(4-methoxybenzyl)-trichloroacetimidate

(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol

Downstream raw materials:

(2R)-methoxy-4-[2-methyl-3-(phenylsulfonyl)propoxymethyl]benzene

(E)-(2R,7R)-3-Benzenesulfonyl-7-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-2,6-dimethyl-non-5-en-4-one

(E)-(2S,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-2,6-dimethyl-non-5-en-4-one