Technology Process of 5-Nonen-4-one,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methoxy]-2,
6-dimethyl-3-(phenylsulfonyl)-, (2R,5E,7R)-
There total 10 articles about 5-Nonen-4-one,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methoxyphenyl)methoxy]-2,
6-dimethyl-3-(phenylsulfonyl)-, (2R,5E,7R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / imidazole / dimethylformamide / 36 h
2: 94 percent / H2 / Pd/C / acetic acid; ethanol / 24 h / 3102.9 Torr
3: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -50 deg C, 15 min, 2.) CH2Cl2, -50 deg C to r.t.
4: 89 percent / NaH / benzene / 1.) 1 h, 2.) 60 deg C, 3 h
5: 1.) n-BuLi, MgBr2*Et2O / 1.) hexane, benzene, THF, Et2O, -78 deg C, 25 min; 0 deg C, 15 min, 2.) hexane, benzene, THF, Et2O, r.t., 1 h
With
1H-imidazole; n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; magnesium bromide;
palladium on activated charcoal;
In
ethanol; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1039/a805856c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / H2 / Pd/C / acetic acid; ethanol / 24 h / 3102.9 Torr
2: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) CH2Cl2, -50 deg C, 15 min, 2.) CH2Cl2, -50 deg C to r.t.
3: 89 percent / NaH / benzene / 1.) 1 h, 2.) 60 deg C, 3 h
4: 1.) n-BuLi, MgBr2*Et2O / 1.) hexane, benzene, THF, Et2O, -78 deg C, 25 min; 0 deg C, 15 min, 2.) hexane, benzene, THF, Et2O, r.t., 1 h
With
n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; magnesium bromide;
palladium on activated charcoal;
In
ethanol; acetic acid; benzene;
DOI:10.1039/a805856c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hexane; CH2Cl2 / 0 °C
2: 98 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
3: 93 percent / NBS, Ph3P / CH2Cl2 / 1 h / Ambient temperature
4: 96 percent / DBU / benzene / 2 h / Ambient temperature
5: 85 percent / oxone / H2O / 16 h / Ambient temperature
6: 1.) n-BuLi, MgBr2*Et2O / 1.) hexane, benzene, THF, Et2O, -78 deg C, 25 min; 0 deg C, 15 min, 2.) hexane, benzene, THF, Et2O, r.t., 1 h
With
Oxone; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; magnesium bromide;
In
diethyl ether; hexane; dichloromethane; water; benzene;
DOI:10.1039/a805856c
