isopropyl 4-(bromomethyl)benzoate

Base Information

• Chemical Name: isopropyl 4-(bromomethyl)benzoate
• CAS No.: 28188-39-8
• Molecular Formula: C₁₁H₁₃BrO₂
• Molecular Weight: 257.127
• Mol file: 28188-39-8.mol

Synonyms:isopropyl 4-(bromomethyl)benzoate

Chemical Property of isopropyl 4-(bromomethyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of isopropyl 4-(bromomethyl)benzoate

There total 3 articles about isopropyl 4-(bromomethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyll 4-methylbenzoate (19277-55-5) → isopropyl 4-(bromomethyl)benzoate (28188-39-8)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; for 12h; Reflux;

DOI:10.1016/j.ejmech.2008.11.007

Reference yield:

4-bromomethylbenzoic Acid (6232-88-8) + isopropyl alcohol (67-63-0,8013-70-5) → isopropyl 4-(bromomethyl)benzoate (28188-39-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2019.05.032

Reference yield:

p-Toluic acid (99-94-5) → isopropyl 4-(bromomethyl)benzoate (28188-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Schlenk technique; Inert atmosphere

1.2: 20 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); N,N-dimethyl-formamide; In tetrachloromethane; dichloromethane;

upstream raw materials:

isopropyll 4-methylbenzoate

p-Toluic acid

4-bromomethylbenzoic Acid

isopropyl alcohol

Downstream raw materials:

isopropyl 4-({allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino}-methyl)-benzoate