2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid

Base Information

• Chemical Name: 2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid
• CAS No.: 136192-78-4
• Molecular Formula: C₁₅H₁₄N₂O₅S
• Molecular Weight: 334.353
• Mol file: 136192-78-4.mol

Synonyms:2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid

Chemical Property of 2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid

There total 2 articles about 2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

4,6-dimethoxypyrimidin-2-yl methyl sulfone (113583-35-0) + 2-Acetyl-6-mercaptobenzoic acid (136192-83-1) → 2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid (136192-78-4)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 2.5h;

DOI:10.1002/(SICI)1096-9063(199608)47:4<327::AID-PS432>3.0.CO;2-U

Reference yield:

2-Amino-6-acetylbenzoic acid (103440-81-9) → 2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid (136192-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂; aq. HCl

1.2: aq. disodium sulfide; NaOH / 2 h / 20 °C

2.1: 34 percent / aq. NaOH / dimethylformamide / 2.5 h / 20 - 60 °C

With hydrogenchloride; sodium hydroxide; sodium nitrite; In N,N-dimethyl-formamide; 1.1: Diazotization / 1.2: Substitution / 2.1: Arylation;

DOI:10.1002/(SICI)1096-9063(199608)47:4<327::AID-PS432>3.0.CO;2-U

Reference yield: 32.0%

2-Acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoic acid (136192-78-4) + methyl iodide (74-88-4) → Methyl 2-acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoate (136192-69-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1002/(SICI)1096-9063(199608)47:4<327::AID-PS432>3.0.CO;2-U

upstream raw materials:

4,6-dimethoxypyrimidin-2-yl methyl sulfone

2-Acetyl-6-mercaptobenzoic acid

2-Amino-6-acetylbenzoic acid

Downstream raw materials:

Methyl 2-acetyl-6-[(4,6-dimethoxypyrimidin-2-yl)thio]benzoate