Technology Process of 1-(3-benzyloxy-4-methoxybenzyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
There total 19 articles about 1-(3-benzyloxy-4-methoxybenzyl)-7-benzyloxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(3-benzyloxy-4-methoxyphenyl)-N-(4-benzyloxy-3-methoxyphenethyl)-N-methylacetamide;
With
trichlorophosphate;
In
acetonitrile;
for 3h;
Reflux;
Inert atmosphere;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
Inert atmosphere;
Cooling with ice;
DOI:10.1021/jo201056f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / ethanol / 20 h / 20 °C / Inert atmosphere
2.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2.5 h / -10 °C / Inert atmosphere
3.1: sodium tetrahydroborate; diphenyl diselenide; sodium hydroxide / ethanol / 18 h / 40 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere
5.1: sodium hydroxide / chloroform / 0 - 20 °C
6.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere
6.2: 20 °C / Inert atmosphere; Cooling with ice
With
sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; potassium carbonate; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
methanol; ethanol; chloroform; N,N-dimethyl-formamide; toluene; acetonitrile;
5.1: Schotten-Baumann reaction / 6.1: Bischler-Napieralski cyclization;
DOI:10.1021/jo201056f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium iodide; potassium hydroxide / ethanol / 90 °C
1.2: 16 h / 100 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / chloroform / 0 - 20 °C
4.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere
4.2: 20 °C / Inert atmosphere; Cooling with ice
With
oxalyl dichloride; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
ethanol; chloroform; toluene; acetonitrile;
3.1: Schotten-Baumann reaction / 4.1: Bischler-Napieralski cyclization;
DOI:10.1021/jo201056f
