(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Base Information

• Chemical Name: (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide
• CAS No.: 1557243-20-5
• Molecular Formula: C₂₀H₁₉F₄NO₂
• Molecular Weight: 381.37
• Mol file: 1557243-20-5.mol

Synonyms:(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Chemical Property of (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

There total 5 articles about (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H13ClO (1610023-35-2) + 5-fluoro-2-(2,2,2-trifluoroethoxy)aniline hydrochloride (1384429-77-9) → (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide (1557243-20-5)

Guidance literature:

With triethylamine; In diethyl ether; at 0 ℃; Inert atmosphere;

Reference yield:

(±)-trans-ethyl 2,2-dimethyl-3-phenylcyclopropanecarboxylate (61751-36-8,126087-66-9,126087-69-2) → (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide (1557243-20-5)

Guidance literature:

Multi-step reaction with 4 steps

1: water; sodium hydroxide / tetrahydrofuran / 60 °C

2: Lux C₄ / methanol / 35 °C / 75007.5 Torr

3: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / diethyl ether / 0 °C / Inert atmosphere

With oxalyl dichloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

ethyl 3-phenyl-2-propenoate (103-36-6) → (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide (1557243-20-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: water; sodium hydroxide / tetrahydrofuran / 60 °C

3.1: Lux C₄ / methanol / 35 °C / 75007.5 Torr

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / diethyl ether / 0 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;

upstream raw materials:

(±)-trans-ethyl 2,2-dimethyl-3-phenylcyclopropanecarboxylate

ethyl 3-phenyl-2-propenoate

(±)-trans-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid

(+)-trans-(1R,3R)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid