(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Base Information

Chemical Name:(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide
CAS No.:1557243-20-5
Molecular Formula:C₂₀H₁₉F₄NO₂
Molecular Weight:381.37
Hs Code.:

Synonyms:(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

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Chemical Property of (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

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Technology Process of (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

There total 5 articles about (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610023-35-2
C₁₂H₁₃ClO

: 1384429-77-9
5-fluoro-2-(2,2,2-trifluoroethoxy)aniline hydrochloride

: 1557243-20-5
(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Guidance literature:: With triethylamine; In diethyl ether; at 0 ℃; Inert atmosphere;

Reference yield:

: 61751-36-8,126087-66-9,126087-69-2
(±)-trans-ethyl 2,2-dimethyl-3-phenylcyclopropanecarboxylate

: 1557243-20-5
(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / tetrahydrofuran / 60 °C

2: Lux C₄ / methanol / 35 °C / 75007.5 Torr

3: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / diethyl ether / 0 °C / Inert atmosphere

With oxalyl dichloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 103-36-6
ethyl 3-phenyl-2-propenoate

: 1557243-20-5
(1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: water; sodium hydroxide / tetrahydrofuran / 60 °C

3.1: Lux C₄ / methanol / 35 °C / 75007.5 Torr

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / diethyl ether / 0 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;