Technology Process of 2-<(phenylthio)acetyl>-2,3,4,5,6,7-hexahydro-1,5-methano-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole
There total 11 articles about 2-<(phenylthio)acetyl>-2,3,4,5,6,7-hexahydro-1,5-methano-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 21 ℃;
for 12h;
DOI:10.1021/jo00027a016
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 73 percent / aq. acetic acid / 10 h / Heating
2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C
3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H2O / 2 h / 0 °C
4: tetra-N-benzylammonium chloride, 30percent NaOH / CH2Cl2 / 1 h
5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C
6: 1.) triethylamine 2.) 58percent aq. ammonium hydroxide / 1.) methylene dichloride, 0 deg C, 1 h 2.) THF, 30 min
7: 100 percent / sodium borohydride / methanol; tetrahydrofuran / 2 h / 21 °C
8: 90 percent / trifluoroacetic acid / CH2Cl2 / 12 h / 25 °C
9: 56 percent / diborane / tetrahydrofuran / 2 h / Heating
10: 96 percent / triethylamine / CH2Cl2 / 12 h / 21 °C
With
hydrogenchloride; lithium hydroxide; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; Bn4NCl; dimethoxypropane; acetic acid; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; diborane;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00027a016
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 73 percent / aq. acetic acid / 10 h / Heating
2: 99.6 percent / concd HCl, dimethoxypropane / 2 h / 20 °C
3: 85 percent / dichlorodicyanoquinone / tetrahydrofuran; H2O / 2 h / 0 °C
4: tetra-N-benzylammonium chloride, 30percent NaOH / CH2Cl2 / 1 h
5: aq. lithium hydroxide / tetrahydrofuran / 1 h / 23 °C
6: 1.) triethylamine 2.) 58percent aq. ammonium hydroxide / 1.) methylene dichloride, 0 deg C, 1 h 2.) THF, 30 min
7: 100 percent / sodium borohydride / methanol; tetrahydrofuran / 2 h / 21 °C
8: 90 percent / trifluoroacetic acid / CH2Cl2 / 12 h / 25 °C
9: 56 percent / diborane / tetrahydrofuran / 2 h / Heating
10: 96 percent / triethylamine / CH2Cl2 / 12 h / 21 °C
With
hydrogenchloride; lithium hydroxide; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; Bn4NCl; dimethoxypropane; acetic acid; triethylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; diborane;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00027a016
