8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

Base Information

Chemical Name:8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine
CAS No.:1350545-15-1
Molecular Formula:C₂₈H₃₄N₈
Molecular Weight:482.632
Hs Code.:

Synonyms:8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

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Chemical Property of 8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

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Technology Process of 8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

There total 7 articles about 8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

: 842129-18-4
4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

: 103-72-0
phenyl isothiocyanate

: 1350545-15-1
8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 10.5h; Reflux;

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1350545-15-1
8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -60 °C

2: butan-1-ol / 5 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm301365e

Reference yield:

: 842129-17-3
N⁴-cyclohexyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

: 1350545-15-1
8-phenylamino-9-cyclohexyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / Reflux

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm301365e