4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Base Information

Chemical Name:4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine
CAS No.:842129-18-4
Molecular Formula:C₂₁H₃₁N₇
Molecular Weight:381.524
Hs Code.:

Synonyms:4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

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Chemical Property of 4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

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Technology Process of 4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

There total 5 articles about 4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: 842129-17-3
N⁴-cyclohexyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

: 842129-18-4
4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Guidance literature:: With thiophene; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; at 50 ℃;

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 842129-18-4
4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -60 °C

2: butan-1-ol / 5 h / 90 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm301365e

Reference yield:

: 890094-40-3
2-chloro-N-cyclohexyl-5-nitropyrimidin-4-amine

: 842129-18-4
4-cyclohexylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: butan-1-ol / 5 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; In methanol; butan-1-ol;
DOI:10.1021/jm301365e