1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

Base Information

Chemical Name:1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea
CAS No.:1380281-50-4
Molecular Formula:C₂₇H₂₅F₂N₅O
Molecular Weight:473.525
Hs Code.:

Synonyms:1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

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Chemical Property of 1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

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Technology Process of 1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

There total 9 articles about 1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 75-44-5
phosgene

: 1380281-67-3
[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-[6-(2,4-difluorophenyl)-pyridin-2-yl]amine

: 1380281-50-4
1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

Guidance literature:: phosgene; [5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-[6-(2,4-difluorophenyl)-pyridin-2-yl]amine; In toluene; for 3h;

With ammonia; In methanol; toluene;

Reference yield:

: 1380281-65-1
5-(2-tert-butyl-pyrimidin-4-yl)-2-methylphenylamine

: 1380281-50-4
1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 3 h / 75 °C

3: toluene / 3 h

With sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In ethanol; water; toluene; 2: Suzuki Coupling;

Reference yield:

: 2458-12-0
3-amino-p-toluic acid

: 1380281-50-4
1-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenyl]-1-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / water / 18 h / 20 °C

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 0.5 h

2.2: 48 h / 20 °C

3.1: diethyl ether; tetrahydrofuran / 20 °C / Cooling

4.1: N,N-dimethyl-formamide / 2 h / 60 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

6.1: hydrogenchloride / 1,4-dioxane / 18 h

7.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 3 h / 75 °C

9.1: toluene / 3 h

With 4-methyl-morpholine; hydrogenchloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium carbonate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; 8.1: Suzuki Coupling;