(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

Base Information

Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester
CAS No.:82838-29-7
Molecular Formula:C₃₀H₃₇F₃O₄
Molecular Weight:518.617
Hs Code.:

(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

There total 4 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 82799-00-6
(3aS,4aR,8S,8aS,10aR)-8-Hydroxy-1-isopropylidene-3a,8a-dimethyl-5-methylene-dodecahydro-benzo[f]azulen-2-one

: 82838-29-7
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

Guidance literature:: With pyridine; In tetrachloromethane; Ambient temperature; overnight;
DOI:10.1021/jo00142a024

Reference yield:

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 82838-29-7
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride, sodium chloride / 60 h / Heating

2: 100 percent / pyridine / CCl₄ / Ambient temperature; overnight

With pyridine; thionyl chloride; sodium chloride; In tetrachloromethane;
DOI:10.1021/jo00142a024

Reference yield:

: 82798-98-9
13-keto-1(S),11(R)-dolabella-3(E),7(E),12⁽¹⁸⁾-triene

: 82838-29-7
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (3aS,4aR,8S,8aS,10aR)-1-isopropylidene-3a,8a-dimethyl-5-methylene-2-oxo-tetradecahydro-benzo[f]azulen-8-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature; Na₂HPO₄-buffer

2: 17 percent / BF₃-etherate / diethyl ether / 0.25 h / 0 °C

3: 100 percent / pyridine / CCl₄ / Ambient temperature; overnight

With pyridine; boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane; diethyl ether; dichloromethane;
DOI:10.1021/jo00142a024