(E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

Base Information

Chemical Name:(E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime
CAS No.:88643-67-8
Molecular Formula:C₁₃H₂₆ClNOSi
Molecular Weight:275.894
Hs Code.:

Synonyms:(E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

Suppliers and Price of (E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

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Technology Process of (E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

There total 3 articles about (E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 63603-22-5
trans-2-Chloro-3-methylcyclohexan-1-one

: 88643-67-8
(E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

Guidance literature:: With O-(tert-butyldimethylsilanyl)hydroxylamine; 4 A molecular sieve; In chloroform;
DOI:10.1021/jo00179a011

Reference yield:

: 930-68-7
cyclohexenone

: 88643-67-8
(E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) CuI, 2.) NEt₃ / 1.) Et₂O, THF, -40 to -50 deg C, 30 min., 2.) HMPA, -70 deg C, 1 h

2: 1.) methyllithium, 2.) N-chlorosuccinimide / 1.) THF, Et₂O, r.t., 1 h, 2.) -70 deg C, 40 min.,

3: 85 percent / O-(tert-Butyldimethylsilyl)hydroxylamine / activated molecular sieves (4 Angstroem) / CHCl₃

With N-chloro-succinimide; copper(l) iodide; O-(tert-butyldimethylsilanyl)hydroxylamine; methyllithium; triethylamine; 4 A molecular sieve; In chloroform;
DOI:10.1021/jo00179a011

Reference yield:

: 74173-18-5,83149-31-9,55373-58-5
trimethyl(3-methylcyclohex-1-enyloxy)silane

: 88643-67-8
(E)-trans-2-Chloro-3-methylcyclohexan-1-one (tert-butyldimethylsilyl)oxime

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) methyllithium, 2.) N-chlorosuccinimide / 1.) THF, Et₂O, r.t., 1 h, 2.) -70 deg C, 40 min.,

2: 85 percent / O-(tert-Butyldimethylsilyl)hydroxylamine / activated molecular sieves (4 Angstroem) / CHCl₃

With N-chloro-succinimide; O-(tert-butyldimethylsilanyl)hydroxylamine; methyllithium; 4 A molecular sieve; In chloroform;
DOI:10.1021/jo00179a011