tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate
CAS No.:1352934-25-8
Molecular Formula:C₂₈H₂₉F₃N₄O₅
Molecular Weight:558.557
Hs Code.:

Synonyms:tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

There total 6 articles about tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193269-78-2
3-aminoazetidine-1-carboxylic acid tert-butyl ester

: 1352933-78-8
2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetic acid

: 1352934-25-8
tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

Guidance literature:: 2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

3-aminoazetidine-1-carboxylic acid tert-butyl ester; With benzotriazol-1-ol; In dichloromethane; at 20 ℃;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1352934-25-8
tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.2: pH ~ 5

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

4.2: 20 °C

With water; sodium hydrogencarbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 247113-89-9
6-(trifluoromethyl)quinolin-4-amine

: 1352934-25-8
tert-butyl 3-(2-(((benzyloxy)carbonyl)(6-(trifluoromethyl)quinolin-4-yl)amino)acetamido)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethyl acetate; water / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.2: pH ~ 5

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

4.2: 20 °C

With water; sodium hydrogencarbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;